RYOKA SYSTEMS WILL DISTRIBUTE IO INFORMATICS SENTIENT DESKTOP IN JAPAN

EMERYVILLE, CA - May 16, 2005 --- IO Informatics, Inc., today announced that it has reached an agreement with Ryoka Systems, Inc. to distribute in Japan Sentient™ Desktop, IO Informatics’ lightweight product that helps researchers get the whole picture by bringing together all relevant data in a common environment.

"We are pleased to introduce our products to Japan through Ryoka Systems", said Pat Rougeau, President and CEO of IO Informatics. “Ryoka represents high-quality IT products and services in Japan, including molecular design and simulation and 3D imaging products, and has a long history of bringing valuable state-of-the-art solutions to the Japanese scientific market. They are an excellent fit to offer Sentient™ Desktop to Japanese life scientists."

"We are delighted to be representing IO Informatics in Japan,” said Junichi Goto, General Manager, the Computational Science Dept. of Science & Technology System Division of Ryoka Systems Inc. Not only our staff but also all the customers we initially visited are very impressed by the product. Early on we already understood the value and uniqueness of Sentient Desktop.” He added, “The knowledge-building environment of Sentient Desktop complements the products of the other companies we represent in Japan, and allows us to offer more value to our customers. We are particularly impressed with how stable and user oriented it is, and look forward to introducing it to Japan."

About Ryoka Systems, Inc.
Ryoka Systems Incorporated was established in 1970 to provide and support Mitsubishi Kasei Corporation (currently Mitsubishi Chemical Company) with information processing systems. In the field of computational science and technology services, RSI provides state-of-the-art computer applications technology through association with companies that are at the leading edge of technology. They offer powerful support for the "efficient management of R&D". For more information, please visit the web site at www.rsi.co.jp/.

About IO Informatics
IO Informatics is at the forefront of a global revolution in software methods that use intelligent agents to apply a multidimensional approach to data integration. These agents interconnect data and establish relationships among them to automate the knowledge building process. By applying its intellectual property and breakthrough software architecture, IO has produced tools that integrate heterogeneous data sources (e.g. proprietary spreadsheets, Web files, images, and public and proprietary databases) to solve problems in fields where complex data are involved, such as medical, pharmaceutical R&D, and life sciences research. The company’s Sentient™ software enables secure, unified use of previously disconnected, heterogeneous data and distributed information at a fraction of the cost and time previously required. Products using Sentient™ software allow researchers to build knowledge, using either a single laptop computer or an enterprise-wide network, without the need for programming or changes to the enterprise IT infrastructure. Founded in 2003, IO Informatics is located in Emeryville, California. For more information, please visit the company web site at www.io-informatics.com.

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